Daptomycin is approved for which infections?

Daptomycin is approved for which infections?

• A. Pneumonia
• B. Meningitis
• C. Bacteremia, endocarditis, and skin/soft tissue infections
• D. Urinary tract infections

Answer: (C)

Daptomycin is a Gram-positive–active, bactericidal antibiotic used for conditions caused by MRSA and VRE. It is approved for complicated skin and soft tissue infections, bacteremia, and right-sided infective endocarditis. It is not used for pneumonia because it is inactivated by pulmonary surfactant, which makes it ineffective in the lungs. It also doesn’t have good CSF penetration, so meningitis isn’t an indication, and there’s no approved use for urinary tract infections. So the infections it’s approved for are bacteremia, endocarditis, and skin/soft tissue infections.

Daptomycin is a Gram-positive–active, bactericidal antibiotic used for conditions caused by MRSA and VRE. It is approved for complicated skin and soft tissue infections, bacteremia, and right-sided infective endocarditis. It is not used for pneumonia because it is inactivated by pulmonary surfactant, which makes it ineffective in the lungs. It also doesn’t have good CSF penetration, so meningitis isn’t an indication, and there’s no approved use for urinary tract infections. So the infections it’s approved for are bacteremia, endocarditis, and skin/soft tissue infections.