Linezolid has activity against which resistant organisms?

Linezolid has activity against which resistant organisms?

• A. Pseudomonas aeruginosa
• B. MRSA and VRE
• C. CRE
• D. ESBL-producing Enterobacteriaceae

Answer: (B)

Linezolid is an oxazolidinone that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing formation of the initiation complex. This gives strong activity against Gram-positive cocci, including MRSA and vancomycin-resistant Enterococcus (VRE). It does not reliably cover Gram-negative bacteria, which is why organisms like Pseudomonas aeruginosa are not susceptible. Carbapenem-resistant Enterobacteriaceae (CRE) and ESBL-producing Enterobacteriaceae are Gram-negative and generally not susceptible to linezolid. Therefore, MRSA and VRE are the resistant organisms against which linezolid has activity.

Linezolid is an oxazolidinone that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing formation of the initiation complex. This gives strong activity against Gram-positive cocci, including MRSA and vancomycin-resistant Enterococcus (VRE). It does not reliably cover Gram-negative bacteria, which is why organisms like Pseudomonas aeruginosa are not susceptible. Carbapenem-resistant Enterobacteriaceae (CRE) and ESBL-producing Enterobacteriaceae are Gram-negative and generally not susceptible to linezolid. Therefore, MRSA and VRE are the resistant organisms against which linezolid has activity.