What is a common PK/PD target for vancomycin dosing?

What is a common PK/PD target for vancomycin dosing?

• A. Cmax/MIC around 8–12
• B. AUC/MIC around 400–600
• C. Time above MIC > 24 hours
• D. Peak concentration around 100 mg/L

Answer: (B)

Vancomycin efficacy is driven by drug exposure relative to bacterial susceptibility, captured as the AUC/MIC ratio. The common dosing target is an AUC over 24 hours divided by the MIC of the organism of about 400–600 mg·h/L. This exposure range provides good clinical effect while keeping nephrotoxicity risk reasonable. A Cmax/MIC around 8–12 is typical for aminoglycosides, not vancomycin. Time above MIC for more than 24 hours is more relevant to beta-lactams. A peak concentration around 100 mg/L isn’t a standard vancomycin target. In practice, dosing is guided to achieve the 400–600 AUC/MIC range, often using AUC-based methods rather than troughs alone.

Vancomycin efficacy is driven by drug exposure relative to bacterial susceptibility, captured as the AUC/MIC ratio. The common dosing target is an AUC over 24 hours divided by the MIC of the organism of about 400–600 mg·h/L. This exposure range provides good clinical effect while keeping nephrotoxicity risk reasonable. A Cmax/MIC around 8–12 is typical for aminoglycosides, not vancomycin. Time above MIC for more than 24 hours is more relevant to beta-lactams. A peak concentration around 100 mg/L isn’t a standard vancomycin target. In practice, dosing is guided to achieve the 400–600 AUC/MIC range, often using AUC-based methods rather than troughs alone.