Which antibiotic can cause red man syndrome if infused too rapidly?

Which antibiotic can cause red man syndrome if infused too rapidly?

• A. Linezolid.
• B. Vancomycin.
• C. Rifampin.
• D. Doxycycline.

Answer: (B)

Red man syndrome is an infusion-related reaction caused by rapid IV administration of vancomycin. The quick infusion can trigger histamine release from mast cells, leading to flushing and redness of the face, neck, and upper body, sometimes with itching and low blood pressure. It’s not a true allergy, so slowing the infusion rate reduces the risk, and antihistamines can be used if needed. Among the antibiotics listed, vancomycin is classically associated with this reaction, whereas linezolid, rifampin, and doxycycline do not typically cause red man syndrome in the same way. To prevent it, infuse vancomycin slowly—usually over at least 60 minutes for standard doses.

Red man syndrome is an infusion-related reaction caused by rapid IV administration of vancomycin. The quick infusion can trigger histamine release from mast cells, leading to flushing and redness of the face, neck, and upper body, sometimes with itching and low blood pressure. It’s not a true allergy, so slowing the infusion rate reduces the risk, and antihistamines can be used if needed. Among the antibiotics listed, vancomycin is classically associated with this reaction, whereas linezolid, rifampin, and doxycycline do not typically cause red man syndrome in the same way. To prevent it, infuse vancomycin slowly—usually over at least 60 minutes for standard doses.