Which fourth-generation cephalosporin covers Pseudomonas aeruginosa?

Which fourth-generation cephalosporin covers Pseudomonas aeruginosa?

• A. Cefepime
• B. Cefotetan
• C. Cefixime
• D. Cefpodoxime

Answer: (A)

Cefepime, a fourth-generation cephalosporin, has reliable activity against Pseudomonas aeruginosa. This generation is notable for broad Gram-negative coverage that includes Pseudomonas, while still giving good Gram-positive activity and stability against many beta-lactamases. That makes it the go-to option when a pseudomonal infection is a concern or when hospital-associated pathogens are suspected. The other drugs listed lack true pseudomonal coverage: cefotetan is a second-generation agent with anaerobic activity and does not cover Pseudomonas, while cefixime and cefpodoxime are oral third-generation agents with limited or no activity against Pseudomonas. So, cefepime is the best choice for pseudomonal coverage.

Cefepime, a fourth-generation cephalosporin, has reliable activity against Pseudomonas aeruginosa. This generation is notable for broad Gram-negative coverage that includes Pseudomonas, while still giving good Gram-positive activity and stability against many beta-lactamases. That makes it the go-to option when a pseudomonal infection is a concern or when hospital-associated pathogens are suspected. The other drugs listed lack true pseudomonal coverage: cefotetan is a second-generation agent with anaerobic activity and does not cover Pseudomonas, while cefixime and cefpodoxime are oral third-generation agents with limited or no activity against Pseudomonas. So, cefepime is the best choice for pseudomonal coverage.