Which third-generation cephalosporin covers Pseudomonas aeruginosa?

Which third-generation cephalosporin covers Pseudomonas aeruginosa?

• A. Cefepime
• B. Cefotaxime
• C. Ceftazidime
• D. Ceftriaxone

Answer: (C)

Ceftazidime is the third-generation cephalosporin that reliably covers Pseudomonas aeruginosa. Among this generation, it has the spectrum that includes Pseudomonas due to its ability to reach and inhibit Pseudomonas cell wall synthesis while being relatively more stable to the enzymes that inactivate many beta-lactams in this organism. Cefotaxime and ceftriaxone, while effective against many Enterobacterales, do not reliably cover Pseudomonas. Cefepime, though good against Pseudomonas, is a fourth-generation cephalosporin, not third-generation. So, for anti-Pseudomonal activity within the third generation, ceftazidime is the best choice.

Ceftazidime is the third-generation cephalosporin that reliably covers Pseudomonas aeruginosa. Among this generation, it has the spectrum that includes Pseudomonas due to its ability to reach and inhibit Pseudomonas cell wall synthesis while being relatively more stable to the enzymes that inactivate many beta-lactams in this organism. Cefotaxime and ceftriaxone, while effective against many Enterobacterales, do not reliably cover Pseudomonas. Cefepime, though good against Pseudomonas, is a fourth-generation cephalosporin, not third-generation. So, for anti-Pseudomonal activity within the third generation, ceftazidime is the best choice.